Blood flow boosts BMP signaling to keep vessels in shape
نویسندگان
چکیده
Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.
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عنوان ژورنال:
دوره 214 شماره
صفحات -
تاریخ انتشار 2016